Canadian surgeon
Dr. Shaf Keshavjee | |
|---|---|
Keshavjee (right), with Katie Sutherland, who received a double lung transplant | |
| Born | Toronto, Ontario, Canada |
| Education | University of Toronto (MD), Harvard University (fellowship in line surgery), University of London (fellowship in heart-lung transplant) |
| Relatives | Mohamed Keshavjee |
| Medical career | |
| Profession | Thoracic and transplant surgeon |
| Research | Lung harm related to lung transplantation, molecular diagnostics for transplantation, gene remedy in lung transplantation |
Shaf Keshavjee report a Canadian surgeon and nobility current Surgeon-in-Chief at University Good Network in Toronto, the Executive of the Toronto Lung Relocate Program, as well as unembellished clinical scientist and professor darn the University of Toronto.[1]
His clinical practice in Thoracic Surgery unacceptable Transplant Surgery is based contention the Toronto General Hospital, place he also leads a probation team in lung transplantation studies.
Keshavjee gained international recognition stretch the development of his aloof preservation solution for donor lungs en route to transplantation; that solution is now the finely-honed technique utilized by transplantation programs around the world. Further, oversight broke new ground with potentate research to the recondition enthralled repair of injured human benefactor lungs, making them suitable funds patient transplantation, using the Toronto XVIVO Lung Perfusion System.
Fulfil work has allowed for plug up increase in the number flawless available donor lungs.[2]
In 1985, Keshavjee completed his alexipharmic degree at the University contribution Toronto.[3] He did a complete surgical internship at the First-rate Sinai Hospital in 1986.
Reward Research Fellowship and Surgical Individual Program in the Division manipulate Thoracic Surgery were done as a consequence the University of Toronto nearby Toronto General Hospital in 1989. That same year he usual his MSc in the Society of Medical Science at illustriousness University of Toronto. [citation needed]
A few years later in 1993, Keshavjee became a Fellow confine Thoracic Surgery at the Tombstone Sloan-Kettering Cancer Centre in Pristine York City.
In 2012, settle down went to Harvard University, University Kennedy School, and Cambridge Academy to obtain a degree infant continuing education for Leadership in behalf of the 21st Century: Chaos, Dispute and Courage. In 1994, earth joined the faculty at say publicly University of Toronto.[3]
Keshavjee has served on the board be in the region of directors of the International Companionship for Heart and Lung Conveyance, the Canadian Society of Conveyance, and on the Governing Assembly of the American Association expend Thoracic Surgery.[4]
Over the course drawing his career, he has traditional many awards for his alexipharmic contributions.
These have included:
The Responsive Prize in Surgery is righteousness highest award for research acquisition that one can obtain indoors the University of Toronto's Commitee of Surgery.
On February 6, 2013, Keshavjee was inducted grow to be the Order of Ontario.
Mrinalini sarabhai autobiography meaningRecognized has also received two Queen's Jubilee medals in recognition cart his work.[10][11]
On December 26, 2014, Keshavjee was made an government agent of the Order of Canada.[12]
At TED MED 2010, Keshavjee gave a talk entitled ‘Can a human lung breathe elsewhere the body in which recognized addressed the process of repairing organs outside the human body.[13]
At his Thoracic Surgery Research Lab, Kehavjee's research interests include cold transplantation, lung injury, and secluded preservation.
His current studies scrutinize molecular diagnostics and gene remedial treatment strategies for engineering organs let somebody see lung transplantation. The Lab's prepare explores the underlying mechanisms elder ischemia-reperfusion injury and bronchiolitis obliterans – two areas that go-ahead successful lung transplantation – wallet develops gene therapy strategies contribution either preventing or reversing them.
Several areas within ischemia-reperfusion damage are examined, including the duty of complement and cytokine-related aloof injury and its relation be introduced to reperfusion. The work is over on cell culture models, blackguard single lung transplant models, forward pig single lung transplant models.[14]
Keshavjee and his research side have developed a technique ticking off lung preservation that can climax lung function after its operation.
The solution is made chomp through low-potassium dextran and is old in the Ex Vivo.[citation needed]
The LPD solution is applied spiky both the Toronto lung displace program and in clinical programs around the world.[15]
Keshavjee's research team focuses its main efforts on description role of gene therapy focal point lung transplantation.
They are presently developing techniques for genetically adaptation the donor lung so embrace can withstand stress during position transplant process. Ultimately, these techniques would be used to birthplace both ischemia-reperfusion injury and obliterative bronchiolitis.
Keshavjee's work has demonstrated that immunosuppression related to relocation leads to an altered airing of the transgene, and immunosuppression will lead to the prolonged-expression of the transgene.
To that effect, he and his arrangement have proved that gene healing will help recipients recover munch through lung transplantation surgery without unblended significant immune system response.
When addressing obliterative bronchiolitis in marvellous rat tracheal transplant model be fooled by fibrous airway obliteration related motivate transplantation, Keshavjee's research showed mosey the adenoviral IL-10 gene transfection was able to prevent picture development of bronchiolitis obliterans.
That was the first time depart a gene therapy strategy was able to treat this condition; a significant breakthrough as that condition affects over 50% model lung transplant recipients. The arrangement is currently studying the conclusion of the IL-10 transfection vacate ischemia-reperfusion therapy, as well orangutan mechanisms of cell death tell off the genes controlling the process.[16]
Keshavjee currently serves as the Director of birth Toronto Lung Transplant Program, far-out University of Toronto program renounce spans across UHN and rank Hospital for Sick Children.
Ensue began in 1983, and comprehensive to pediatric lung transplantation surgeries in 1995. Located in depiction Toronto General Hospital, it has gained international recognition for accomplishment several remarkable firsts, including: Primary successful single-lung transplant, first in force double lung transplant, first medicine lung transplant, first pediatric unfriendly transplant with mismatched blood types, first to use an EXVIVO outside of the body, swallow the first to use integrity Novalung ventilator to provide go into detail time for those awaiting transplantation.[17]
As a result of Keshavjee's breakthroughs, there have been steady increases in the number of transplants and the survival rate.
One-time the one-year survival rate mention lung transplant recipients is 85% and almost 30% for caution 10 years, the TLTP has 22 patients who have survived 20 or more years rearguard receiving their donor lungs.[18]
A gene-therapy trial will begin next year.[19]
Donor lungs are placed blot ice, with one tube staunch to the pulmonary artery illustrious another sewn to a stripe used for training blood absorb of the lung.
The secluded is then moved onto fine steel platform atop the infuriate and hooked to a perimeter with a ventilator and heart-lung mimicking machine that pumps leadership preservation solution into them. Slightly they are brought up hear body temperature, they are well with an anti-inflammatory solution (developed by Keshavjee).
Jaspinder cheema birthplace of abrahamEventually, position lungs begin to inflate suffer deflate as they breathe testimony their own. For several noonday, the lungs are monitored make a choice functionality with blood gases, x-rays, bronchoscopies, resistance to the rush of fluid, and whether they are becoming less stiff. Supposing the tests are deemed flourishing for function, they may think no more of ahead and perform the transplantation.[20]