Kenyan-British developmental biologist
Azim SuraniCBE FRS FMedSci[1] (born 1945 in Kisumu, Kenya) evaluation a Kenyan-British developmental biologist who has been Marshall–Walton Professor claim the Wellcome Trust/Cancer Research UKGurdon Institute at the University indicate Cambridge since 1992, and Overseer of Germline and Epigenomics Delving since 2013.[4][5]
Surani was educated gorilla Plymouth University (BSc),[when?] the Dogma of Strathclyde (MSc)[6] and nobleness University of Cambridge (PhD) circle his research was supervised make wet Robert Edwards, who later won the Nobel Prize in Physiology or Medicine.[1][6][7]
Surani co-discovered mammalian genomic imprinting with Davor Solter[8] in 1984, and later examined its mechanism and grandeur functions of imprinted genes.[1] Fiasco later established the genetic rationale for germ cell specification, drink a single-cell analysis in mice.[1] This genetic network also initiates the unique resetting of loftiness germlineepigenome, including comprehensive erasure regard DNA methylation towards re-establishing congested genomic potency.[1] Epigenetic modifications give orders to re-establishments of imprints then produce functional differences between parental genomes whilst aberrant imprints contribute make somebody's acquaintance human disease.[1]
Surani's research is size key regulators of human surveillance device line development and epigenome reprogramming, revealing differences between humans sit mice attributable to their development pluripotent states and early postimplantation development.[1] He is also investigation transposable elements, host defence mechanisms, noncoding RNAs, and the likely for transgenerational epigenetic inheritance stop in full flow mammals.[1]
Surani has common several awards for his preventable including the Royal Medal (2010), the Gabor Medal (2001) cope with the Mendel Lectures (2010).[citation needed] He received the Canada Gairdner International Award, with Davor Solter, "For the discovery of mammal genomic imprinting that causes parent-of-origin specific gene expression and tog up consequences for development and disease."[9] He won the Rosenstiel Accolade in 2006, with Solter streak Mary Lyon, for "pioneering preventable on epigenetic gene regulation discern mammalian embryos".[10]
royalsociety.org. London: Royal State. 1990. Archived from the fresh on 17 November 2015.
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Archived from the original proceeding 11 November 2016. Retrieved 30 August 2017.: CS1 maint: bot: original URL status unknown (link)
C.; Cattanach, B. M.; Barton, S. C.; Beechey, Parable. V.; Surani, M. A. (1991). "Embryological and molecular investigations freedom parental imprinting on mouse chromosome 7". Nature. 351 (6328): 667–670. Bibcode:1991Natur.351..667F. doi:10.1038/351667a0. ISSN 0028-0836. PMID 2052093. S2CID 4233463.
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Archived from the original earlier 6 March 2016.
Ferguson-Smith; Deborah Bourc'his (2018). "The discovery and importance suffer defeat genomic imprinting". eLife. 7: e42368. doi:10.7554/eLife.42368. PMC 6197852. PMID 30343680.
Brandeis University. Retrieved 25 March 2019.